正面: Effigy of Queen Elizabeth II facing right, engraver "SB" Susanna Blunt, ruler, country and value; "ELIZABETH II (ML) D‧G‧REGINA CANADA 2 DOLLARS"
背面: The discovery of insulin at the University of Toronto is represented by a maple leaf and traditional symbols: an early insulin vial, an Erlenmeyer flask, a mortar and pestle. The inner core shows insulin in monomeric form, which is highlighted, while the depiction of the hormone at work in the bloodstream extends onto the outer ring, engraver "JK" Jesse Koreck, virtual image above, mintmart laser Maple Leaf divides dates "1921 2021"